Endocrine Abstracts

Background: Bariatric surgery (BS) is a well-documented treatment targeting weight loss excess. There is little evidence on the impact of BS on antenatal glycaemic control. We present four cases of pregnancy post-BS, reviewed in the joint antenatal clinic, who experienced various degrees of hypoglycaemia during pregnancy.Case presentations: Four pregnant women (cases A–D, aged 25–36-years-old, 3–8years pos...

Using nurse led clinics (including telephone and virtual reviews) in NHS Grampian to improve patient satisfaction following a diagnosis of hyperthyroidism.Aims: To reduce waiting times for patients with hyperthyroidism, nurse led clinics were introduced. Telephone and virtual follow up reviews are offered after commencement of thyroid treatment (e.g. anti-thyroid medication or radioactive iodine (RAI)). Nurse-led thyroid clinics aim to i...

Introduction: Disseminated fungal disease is an opportunistic infection mostly seen in immunocompromised patients, however, fungal thyroiditis in this context is rare, with few previously reported cases (predominantly Aspergillus, only one case of paediatric candida thyroiditis). We present a case of Candida tropicalis induced thyroiditis, to highlight this rare (likely underreported) cause of thyroid disease.Case: A 9-y...

Background: Zoledronate is a nitrogen-containing bisphosphonate (BP) recognised for its antiresorptive potency. The pharmacokinetic/pharmacodynamic of zoledronate remains unclear. Although adverse events from overuse of BP is rare, there have been reports of over-treatment resulting in pathophysiological consequences. The current administration regimen is not tailored to the individual’s therapeutic response to zoledronate. Quantifying post-dose serum con...

Background: The active form of vitamin D, 1,25(OH)2D, plays a key role in regulating calcium and phosphorus metabolism and bone homeostasis. In paediatrics, maintaining optimal 1,25(OH)2D levels is crucial for supporting musculoskeletal growth. The hormone also serves as a diagnostic indicator for multiple disorders such as vitamin-D dependent rickets. Current Literature lacks comprehensive reporting of age-specific reference ranges in pa...

Background: Hypogonadotropic hypogonadism is characterised by inadequate secretion of gonadotropins (luteinising hormone (LH) and follicle-stimulating hormone (FSH)) leading to absent, partial or arrested puberty. In males, classical treatment with testosterone promotes virilisation but does not facilitate testicular growth or spermatogenesis. Conversely, treatment with gonadotropins stimulates Sertoli and Leydig cells directly, leading to increased testicular...

Introduction: Despite an increasing incidence of adolescent type 2 diabetes mellitus (T2DM) with its associated morbidities and poor long-term prognosis, there remains uncertainty in its management. The National Institute for Health and Clinical Excellence (NICE) currently recommends initial lifestyle modifications alongside pharmacology management with metformin. Despite being shown to be effective in adults, little is known about the impact of lifestyle inte...

Introduction: DSD includes variations in the development of chromosomal, gonadal, or anatomical sex and can be subdivided into (XY DSD, XX DSD, and sex chromosomal DSD). Most presentations occur in the neonatal period with atypical genitalia or discordant phenotype and antenatal genotype, but later presentations occur raising complex diagnostic and clinical management issues.Objective: To characterise the etiological, cl...

Background: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a relatively rare group of tumors. Traditionally, management of unresectable GEP-NETs was performed by in-person assessment at specialized regional cancer centers. The COVID-19 pandemic resulted in an unprecedent shift towards virtual care. The aim of this study is to evaluate the use of virtual care for GEP-NETs after the COVID-19 pandemic at a high-volume academic cancer center. Me...

Background: G3 NETs are a recently recognized entity and although the treatment recommendations largely follow those for grade 1 and 2 NETs, the outcomes of therapy are inferior. Little is known about the optimal therapy sequencing but small studies have suggested a benefit of multikinase inhibitors. Somatostatin analogs, PRRT and chemotherapy have all been reported to have activity but later lines of therapy are needed. In this study, we sought to evaluate the activity of cab...